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Recent developments in the construction of trans-fused polycyclic ethers
P Andrew Evans1, Bénédicte Delouvrié
1Indiana University, Chemistry Department, 800 E Kirkwood Avenue, Bloomington, IN 47405, USA. paevans@indiana.edu
Current Opinion in Drug Discovery & Development
|December 14, 2002
Summary
New synthetic strategies efficiently assemble complex trans-fused polycyclic ethers. Recent advances enabled total syntheses of ciguatoxin CTX3C and gambierol, but further improvements in selectivity are needed.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
Background:
- Trans-fused polycyclic ethers are complex molecular structures.
- Significant research efforts have focused on their synthesis since the late 1980s.
Purpose of the Study:
- To review synthetic methodology for trans-fused polycyclic ethers developed between 2000 and 2002.
- To highlight efficient strategies for assembling these complex molecules.
Main Methods:
- Focus on iterative, convergent, and cascade/two-directional cyclization strategies.
- Review of synthetic approaches reported in the literature from 2000-2002.
Main Results:
- Development of direct and efficient synthetic routes.
- Successful application of new methods in the total synthesis of ciguatoxin CTX3C and gambierol.
Conclusions:
- Recent synthetic developments provide powerful tools for constructing polycyclic ethers.
- Further advancements in selectivity and versatility are crucial for future progress in this field.