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Updated: Dec 20, 2025
10:38
Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture
Published on: November 22, 2019
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[Androgen receptor isoforms in LNCaP cell and human prostate]
1Department of Urology, Shanghai First People's Hospital, Shanghai 200080, China.
Zhonghua Nan Ke Xue = National Journal of Andrology
|December 14, 2002
Summary
Androgen receptor (AR) isoforms expression varies in benign prostatic hyperplasia (BPH) and prostate cancer tissues. These findings may inform future hormonal therapies for prostate diseases.
Area of Science:
- Molecular Biology
- Endocrinology
- Oncology
Context:
- The androgen receptor (AR) plays a critical role in prostate cancer development and progression.
- Understanding AR isoforms expression is crucial for developing targeted therapies.
Purpose:
- To investigate the differential expression of AR isoforms in human benign prostatic hyperplasia (BPH) and malignant prostatic tissues, as well as in LNCaP cells.
Summary:
- High-resolution isoelectric focusing (IEF) identified three AR isoforms (pI 6.5, 6.0, 5.3) in BPH tissues, prostate cancer specimens, and LNCaP cells.
- Expression patterns varied significantly among patients and between BPH and LNCaP cells.
- Hormone binding assays confirmed that dihydrotestosterone and testosterone inhibited binding to these isoforms.
Impact:
- This study reveals distinct AR isoform expression profiles in benign and malignant prostate conditions.
- The findings suggest potential for personalized hormonal therapy strategies for prostatic diseases based on AR isoform analysis.
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