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[Influenza in the pediatric hospital unit at Antananarivo]

H Raobijaona1, A Rakotondranaivo, D R Rakotoarimanana

  • 1Hôpital général de Befelatanana, Centre Hospitalier Universitaire d'Antananarivo, BP 14 bis, Antananarivo 101, Madagascar.

Archives De L'Institut Pasteur De Madagascar
|December 14, 2002
PubMed

Insights

This study identified the influenza A(H3N2) subtype in 24.1% of Malagasy children hospitalized with acute respiratory infections. Infants aged 1-12 months were most affected, highlighting a key demographic for influenza surveillance.

Area of Science:

  • Virology
  • Pediatric Infectious Diseases
  • Public Health

Context:

  • Acute respiratory infections (ARIs) pose a significant health burden in children globally.
  • Viral etiology is often suspected but difficult to confirm in resource-limited settings.
  • This study focused on hospitalized children in Antananarivo, Madagascar, during a specific period.

Purpose:

  • To investigate the viral causes of ARIs in hospitalized Malagasy children.
  • To identify specific influenza virus subtypes circulating in this population.
  • To analyze the age and sex distribution of confirmed cases.

Summary:

  • Sixty-two nasopharyngeal samples from children (6 days to 14 years) with suspected viral ARI were analyzed.
  • Two diagnostic methods, embryonated eggs and Madin-Darby Canine Kidney (MDCK) cells, were employed.
  • The influenza A(H3N2) subtype was detected in 24.1% of samples, predominantly in infants aged 1-12 months (65.7% of cases).

Impact:

  • Identifies influenza A(H3N2) as a significant pathogen contributing to pediatric ARIs in Madagascar.
  • Provides crucial epidemiological data on age-specific vulnerability to influenza in young children.
  • Informs targeted public health interventions and surveillance strategies for respiratory viruses in the region.

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