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Updated: Sep 28, 2026

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm
Published on: March 1, 2019
[Effect of gamma-aminobutyric acid on the sperm acrosin activity]
Shu-Ling Bian1, Wei Zhang, Hui Zhu
1Department of Physiology, Harbin Medical University, Harbin, Heilongjiang 150086, China.
Objectives:
To investigate the effect of gamma-aminobutyric acid (GABA) on the sperm acrosin activity in normal men and positive antisperm antibody (AsAb) men.
Methods:
Sperm acrosin activity was detected by BAEE/ADH method.
Results:
GABA could increase the sperm acrosin activity in normal and AsAb positive patients (P < 0.01). The results also indicated that GABA significantly increased Na(+)-K(+)-ATPase activity (P < 0.01), Ca(2+)-ATPase activity (P < 0.05) and SOD activity (P < 0.01) of sperm.
Conclusions:
The results demonstrated that GABA could influence the sperm acrosin activity.
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