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[Depression of contractile function and decrease of the effectiveness of oxygen utilization during compensatory heart

F Z Meerson, N P Larionov

    Kardiologiia
    |April 1, 1975
    PubMed
    Summary
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    Heart hypertrophy impairs cardiac function and oxygen use efficiency. This study suggests increased myoplasmic calcium due to impaired calcium pumps causes these changes in hypertrophied hearts.

    Area of Science:

    • Cardiovascular Physiology
    • Cardiac Hypertrophy
    • Mitochondrial Function

    Context:

    • Coarctation of the aorta in rats induces significant heart hypertrophy over 4 months.
    • This model allows for the investigation of functional and metabolic changes in the hypertrophied heart.
    • Previous research indicates altered energy metabolism in cardiac hypertrophy.

    Purpose:

    • To investigate the contractile function and oxygen consumption in isolated working hearts with experimentally induced hypertrophy.
    • To determine the efficacy of oxygen utilization per unit of function in hypertrophied hearts.
    • To explore the underlying mechanisms, specifically the role of calcium handling, in altered cardiac energetics during hypertrophy.

    Summary:

    • Hypertrophied rat hearts exhibited significantly reduced contractile function compared to controls.

    Related Experiment Videos

  • Oxygen consumption remained unchanged, but oxygen utilization efficacy decreased.
  • Glycogen re-synthesis and glycolysis were accelerated, suggesting altered energy substrate utilization.
  • A postulated mechanism involves increased myoplasmic calcium due to reduced sarcoplasmic reticulum calcium pump capacity.

    • Impact:

    • Provides insights into the bioenergetic dysfunction accompanying cardiac hypertrophy.
    • Highlights the potential role of calcium dysregulation in the reduced efficiency of hypertrophied hearts.
    • Suggests potential therapeutic targets related to calcium handling and energy metabolism in heart failure.