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Related Experiment Videos

Neutralizing B cell response in measles.

Fabienne B Bouche1, Oliver T Ertl, Claude P Muller

  • 1Department of Immunology and WHO Collaborating Center for Measles, Laboratoire National de Santé, Luxembourg, Luxembourg.

Viral Immunology
|December 14, 2002
PubMed
Summary
This summary is machine-generated.

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Measles virus (MV) infects B cells, causing immune suppression and antibody production. While antibodies provide protection, their role during infection alongside cellular immunity requires further study.

Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Measles virus (MV) infection is characterized by co-evolving immune suppression and clearance mechanisms.
  • B cells are primary targets of MV, leading to both immune suppression and antibody responses.
  • The precise role of antibodies during measles disease, especially with concurrent cellular immunity, remains incompletely understood.

Purpose of the Study:

  • To elucidate the role of antibody responses in measles virus infection.
  • To investigate the characteristics and targets of protective antibodies against measles.
  • To map neutralizing epitopes on measles virus surface glycoproteins.

Main Methods:

  • Analysis of antibody isotypes (IgM, IgG1) in relation to disease onset.

Related Experiment Videos

  • Characterization of antibody specificity, distinguishing between nucleoprotein and surface glycoprotein targets.
  • Epitope mapping using monoclonal antibodies against measles virus hemagglutinin and fusion proteins.

    • Main Results:

    • Specific IgM antibodies appear with the rash, confirming diagnosis.
    • IgG1 antibodies develop after isotype switching, conferring long-term protection.
    • While nucleoprotein-specific antibodies are abundant, only antibodies targeting hemagglutinin and fusion proteins neutralize the virus and provide protection.
    • Key neutralizing epitopes are primarily located on the hemagglutinin protein.

    Conclusions:

    • Measles virus infection elicits a complex immune response involving B cells, leading to both suppression and antibody generation.
    • Antibodies targeting measles virus surface glycoproteins, particularly hemagglutinin, are crucial for viral neutralization and protection.
    • Detailed epitope mapping provides insights into the functional domains of measles virus glycoproteins targeted by neutralizing antibodies.