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Quantitative characterization of the nucleophile reactivity in penicillin acylase-catalyzed acyl transfer reactions

Maxim I Youshko1, Ghermes G Chilov, Tatyana A Shcherbakova

  • 1Belozersky Institute of Physicochemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia.

Biochimica Et Biophysica Acta
|December 14, 2002
PubMed

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In 1896, the German chemist Paul Walden discovered that he could interconvert pure enantiomeric (+) and (-) malic acids through a series of reactions. This conversion suggested the involvement of optical inversion during the substitution reaction. Further, in 1930, Sir Christopher Ingold described for the first time two different forms of nucleophilic substitution reactions, which are known as SN1 (nucleophilic substitution unimolecular) and SN2 (nucleophilic substitution...
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