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Related Experiment Videos

Safeguarding ART.

Gerald P Schatten1

  • 1Pittsburgh Development Center, Magee Womens Research Institute, Department of Obstetrics, Gynecology & Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. gschatten@magee.edu

Nature Cell Biology
|December 14, 2002
PubMed
Summary
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Assisted reproductive technologies (ART) carry generational risks and require updated safety and success criteria. The biomedical community should consider enhanced governance for ART due to market pressures and potential genetic modifications.

Area of Science:

  • Biomedical Ethics
  • Reproductive Medicine
  • Biotechnology

Background:

  • Assisted reproductive technologies (ART) have unique generational consequences, unlike most medical procedures.
  • Human embryo research funding in the US has been primarily private, with recent expansion into human embryonic stem cell (hESC) and cloning research.
  • The short history of ART complicates establishing consensus on safety and success metrics.

Purpose of the Study:

  • To highlight the ethical and safety concerns surrounding ART.
  • To discuss the impact of market pressures on ART innovation and research.
  • To advocate for increased governance and safeguards in ART.

Main Methods:

  • Review of current practices and ethical considerations in ART.
  • Analysis of the influence of private funding and market demands on reproductive technologies.

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  • Examination of potential risks including unintentional germ-line modifications.

    • Main Results:

    • ART procedures carry inherent risks with long-term, generational implications.
    • Market pressures may drive risky experimentation, including human embryo cloning and unintended genetic modifications.
    • Lack of established safety and success criteria exacerbates these risks.

    Conclusions:

    • ART necessitates a re-evaluation of ethical guidelines and regulatory oversight.
    • There is a growing need for the biomedical community to implement robust safeguards for ART.
    • Further governance is crucial to ensure the responsible advancement of reproductive technologies.