Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytogenetic studies in sideroblastic anemia.

M K Jensen, M Mikkelsen

    Cancer
    |January 1, 1976
    PubMed
    Summary

    Cytogenetic studies revealed a rare 45,X cell line in one patient with acquired sideroblastic anemia. This finding in bone marrow may indicate an underlying neoplastic process or be unrelated to the anemia.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Protein-based HDL subspecies: Rationale and association with cardiovascular disease, diabetes, stroke, and dementia.

    Biochimica et biophysica acta. Molecular and cell biology of lipids·2022
    Same author

    Connecting Scrambling and Work Statistics for Short-Range Interactions in the Harmonic Oscillator.

    Physical review letters·2022
    Same author

    Hospital re-admission after critical care survival: a systematic review and meta-analysis.

    Anaesthesia·2021
    Same author

    Regional Differences in Gamma-Aminobutyric Acid and Glutamate Concentrations in the Healthy Newborn Brain.

    AJNR. American journal of neuroradiology·2021
    Same author

    In Vivo Brain Glutathione is Higher in Older Age and Correlates with Mobility.

    Cerebral cortex (New York, N.Y. : 1991)·2021
    Same author

    Effect of Age on GABA+ and Glutathione in a Pediatric Sample.

    AJNR. American journal of neuroradiology·2020

    Area of Science:

    • Hematology
    • Cytogenetics
    • Oncology

    Background:

    • Acquired sideroblastic anemia is a heterogeneous group of disorders characterized by ineffective erythropoiesis and iron accumulation in bone marrow erythroblasts.
    • Cytogenetic abnormalities are frequently observed in myelodysplastic syndromes, a group that includes some forms of acquired sideroblastic anemia.

    Purpose of the Study:

    • To investigate the cytogenetic profile of patients with acquired sideroblastic anemia.
    • To determine the incidence and significance of chromosomal abnormalities in this patient cohort.

    Main Methods:

    • Bone marrow aspirates were collected from seven patients diagnosed with acquired sideroblastic anemia.
    • Cytogenetic analysis was performed on these bone marrow samples to identify any chromosomal aberrations.

    Main Results:

    • Six out of seven patients exhibited a normal chromosome complement (46,XX or 46,XY).
    • One male patient consistently showed a 45,X cell line across three separate bone marrow aspirates.
    • The cytogenetic literature concerning sideroblastic anemia was reviewed.

    Conclusions:

    • The presence of a 45,X stem line in one patient with acquired sideroblastic anemia is a notable finding.
    • This chromosomal abnormality may be incidental or could suggest an early, yet undiagnosed, neoplastic process.
    • Further investigation is warranted to elucidate the relationship between specific cytogenetic findings and acquired sideroblastic anemia.

    Related Experiment Videos