Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intrauterine position effects.

Bryce C Ryan1, John G Vandenbergh

  • 1Department of Zoology, North Carolina State University, Raleigh, NC 27695, USA. bcryan@unity.ncsu.edu

Neuroscience and Biobehavioral Reviews
|December 14, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serotonin 6 receptor blockade reduces repetitive behavior in the BTBR mouse model of autism spectrum disorder.

Pharmacology, biochemistry, and behavior·2020
Same author

Twenty-Five Years of Endocrine Disruption Science: Remembering Theo Colborn.

Environmental health perspectives·2016
Same author

Novel Object Exploration as a Potential Assay for Higher Order Repetitive Behaviors in Mice.

Journal of visualized experiments : JoVE·2016
Same author

Novel object exploration in the C58/J mouse model of autistic-like behavior.

Behavioural brain research·2014
Same author

Social deficits, stereotypy and early emergence of repetitive behavior in the C58/J inbred mouse strain.

Behavioural brain research·2009
Same author

In utero and lactational exposure to bisphenol A, in contrast to ethinyl estradiol, does not alter sexually dimorphic behavior, puberty, fertility, and anatomy of female LE rats.

Toxicological sciences : an official journal of the Society of Toxicology·2009
Same journal

Dissecting first-episode psychosis heterogeneity with clustering analyses: a systematic review.

Neuroscience and biobehavioral reviews·2026
Same journal

Irisin and anxiety-like behaviors: Mechanistic integration of peripheral-central crosstalk, neuroinflammation and neural plasticity.

Neuroscience and biobehavioral reviews·2026
Same journal

Efficacy of Non-Invasive Brain Stimulation in Alzheimer's Disease: An Umbrella Review of Meta-Analyses.

Neuroscience and biobehavioral reviews·2026
Same journal

Rhythms of interaction - the timescales of social coordination and why they matter.

Neuroscience and biobehavioral reviews·2026
Same journal

Neural Bases of Memory Development: Insights from Magnetic Resonance Imaging.

Neuroscience and biobehavioral reviews·2026
Same journal

Regional heterogeneity of brain insulin resistance: From molecular pathways to neural circuits.

Neuroscience and biobehavioral reviews·2026
See all related articles

Female fetuses exposed to testosterone in utero may develop masculinized traits. This intrauterine position (IUP) effect, observed in mammals, influences adult sex-related characteristics and susceptibility to endocrine disruption.

Area of Science:

  • Reproductive Biology
  • Developmental Endocrinology
  • Behavioral Neuroscience

Background:

  • Individual variability in sex-related traits can be influenced by prenatal hormonal exposure.
  • In litter-bearing mammals, fetuses experience unique hormonal environments based on the sex of adjacent fetuses.
  • This phenomenon, known as intrauterine position (IUP) effects, has implications for understanding sex-specific development.

Purpose of the Study:

  • To review the literature on intrauterine position (IUP) effects and their impact on sex-related traits.
  • To explore the mechanisms by which prenatal hormonal exposure influences adult phenotypes.
  • To highlight the relevance of IUP effects across various scientific disciplines.

Main Methods:

  • Literature review of studies investigating intrauterine position (IUP) effects in mammals.

Related Experiment Videos

  • Analysis of research on hormonal transfer between fetuses in utero.
  • Examination of data on anatomical, physiological, and behavioral changes in adult animals based on prenatal positioning.

    • Main Results:

    • Female fetuses situated between males exhibit more masculinized traits, while those without adjacent males show more feminized traits.
    • Prenatal testosterone transfer from male to adjacent female fetuses is the proposed mechanism.
    • Observed effects include altered hormone levels, reproductive organ development, behavior, and susceptibility to endocrine disruptors.

    Conclusions:

    • Intrauterine position (IUP) significantly influences the development of sex-related traits in mammals.
    • These findings have broad implications for fields including endocrine disruption, toxicology, and animal production.
    • Further research in humans, including twin studies, is warranted to fully understand these prenatal hormonal influences.