Related Experiment Videos
Microtubule associated protein (MAP1A) mRNA was up-regulated by hypergravity in the rat inner ear
Yutaka Takumi1, Naoya Iijima, Nobuyoshi Suzuki
1Department of Otorhinolaryngology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Brain Research. Molecular Brain Research
|December 14, 2002
Abstract:
Differential display analysis of differential mRNA expression in the rat inner ear under hypergravity identified two down- and four up-regulated genes. The up-regulation of microtubule associated protein 1A (MAP1A) in one of these was confirmed by real-time polymerase chain reaction. Since MAP1A is believed to work as a cell stabilizer connecting the actin with microtubule, this is possibly a response to strengthen this stabilizer under hypergravity. The MAP1A gene is the first found to be affected by gravity change in the inner ear.