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1,25-Dihydroxyvitamin D(3) increases striatal GDNF mRNA and protein expression in adult rats
Begoña Sanchez1, Elena Lopez-Martin, Carmen Segura
1Department of Physiology, School of Medicine, University of Santiago de Compostela, Spain.
Brain Research. Molecular Brain Research
|December 14, 2002
Abstract:
Glial cell line-derived neurotrophic factor (GDNF) has been postulated as a possible candidate for therapeutic treatment in Parkinson's disease (PD). Recent in vitro data suggest that 1,25-dihydroxyvitamin D3 [1,25(OH)(2)D(3)] treatment may enhance GDNF mRNA expression. In the present study, using semiquantitative RT-PCR and Western blot, we have shown that 1,25(OH)(2)D(3) administration intraperitoneally, significantly increases GDNF mRNA and protein levels in the striatum of adult rats.