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Published on: October 5, 2016
Development of an injection molded poly(epsilon-caprolactone) intravaginal insert for the delivery of progesterone to
Michael J Rathbone1, Craig R Bunt, Colin R Ogle
1InterAg, 558 Te Rapa Road, PO Box 20055, Hamilton, New Zealand. mjr@interag l.co.nz
Abstract:
This paper reports experiments conducted to research, develop and clinically evaluate an injection molded intravaginal insert manufactured from the biodegradable polyester poly(epsilon-caprolactone). The study demonstrated that it is possible to engineer poly(epsilon-caprolactone) into a shape that is well retained, and can be used as a platform for the controlled delivery of progesterone via the vagina of cows. Field evaluation showed that the poly(epsilon-caprolactone) intravaginal inserts containing 10% (w/w) progesterone were at least as effective clinically as the commercially available CIDR intravaginal insert.
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