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Related Experiment Videos

Development and assessment of mini projectiles as drug carriers.

Gijsbert G P van de Wijdeven1

  • 1Injectile Technologies GmbH, Wiesenring 13a, 04159, Leipzig, Germany. g.v.d.wijdeven@injectile.com

Journal of Controlled Release : Official Journal of the Controlled Release Society
|December 14, 2002
PubMed
Summary

This study introduces novel mini projectiles for drug delivery in farmed animals, offering a safe, non-contact injection method. This technology proved effective in pigs, demonstrating successful vaccine delivery and seroconversion.

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Area of Science:

  • Veterinary Medicine
  • Biotechnology
  • Animal Health

Background:

  • Conventional livestock injections pose risks of cross-contamination and needle-stick injuries.
  • There is a need for innovative drug delivery systems in animal agriculture that enhance safety and efficacy.

Purpose of the Study:

  • To describe and validate a novel mini projectile technology for subcutaneous and intramuscular drug delivery in farmed animals.
  • To assess the safety and efficacy of this new administration method compared to traditional injections.

Main Methods:

  • Development of hollow mini projectiles for drug formulation and compressed air administration.
  • In vitro studies using excised porcine and bovine skin to evaluate penetration parameters.
  • Development of an in vitro skin model with gelatin tissue simulant for penetration visualization and energy determination.

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  • In vivo administration of a model vaccine (BSA) using mini projectiles in pigs.

    • Main Results:

    • Mini projectile design and non-contact administration prevent skin cross-contamination.
    • In vitro analysis determined optimal mini projectile parameters and energy requirements for skin penetration.
    • Tissue damage from mini projectiles was comparable to conventional syringe-needle injections.
    • All pigs administered the BSA vaccine via mini projectiles showed seroconversion, confirming proof of concept.

    Conclusions:

    • The novel mini projectile technology offers a safe and effective alternative for drug and vaccine delivery in livestock.
    • This non-contact method minimizes infection risks and ensures practical application in animal husbandry.
    • Further research can optimize this technology for broader veterinary applications.