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Related Experiment Videos

Accelerated design of bioconversion processes using automated microscale processing techniques.

Gary J Lye1, Parviz Ayazi-Shamlou, Frank Baganz

  • 1The Advanced Centre for Biochemical Engineering, Dept of Biochemical Engineering, University College London, London, UK WC1E 7JE. g.lye@ucl.ac.uk

Trends in Biotechnology
|December 14, 2002
PubMed
Summary

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Microscale processing and automation accelerate bioprocess design and reduce costs. This study reviews microscale unit operations and automated microwell processes, demonstrating their power for efficient bioconversion and product recovery.

Area of Science:

  • Biotechnology and biochemical engineering
  • Process intensification
  • Green chemistry

Background:

  • Microscale processing offers significant advantages in bioprocess design, including increased speed and reduced material consumption.
  • Automation of microscale techniques enhances efficiency, lowers labor intensity, and allows for broader exploration of process variables.
  • The integration of microscale unit operations is key to advancing bioprocess development.

Purpose of the Study:

  • To review recent advancements in microscale unit operations for bioprocessing.
  • To explore the potential of automated, whole-process sequences in microwell formats.
  • To illustrate the benefits of a whole-process approach using a specific bioconversion example.

Main Methods:

  • Review of current literature on microscale microbial fermentation, bioconversion, and product recovery.

Related Experiment Videos

  • Examination of automated microwell systems for integrated bioprocess sequences.
  • Case study: Baeyer-Villiger oxidation of bicyclo[3.2.0]hept-2-en-6-one for lactone production.

    • Main Results:

    • Microscale unit operations are effective for individual bioprocessing steps.
    • Automated microwell formats show promise for streamlined, high-throughput bioprocesses.
    • The Baeyer-Villiger oxidation case study highlights the successful application of microscale and automated techniques for producing optically pure lactones.

    Conclusions:

    • Microscale processing and automation are powerful tools for accelerating bioprocess design and optimization.
    • The whole-process approach in microwell formats enables efficient and versatile bioconversion and product recovery.
    • These technologies contribute to faster development of sustainable and cost-effective biomanufacturing.