Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stem cells for myocardial regeneration.

Donald Orlic1, Jonathan M Hill, Andrew E Arai

  • 1Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, Bethesda, Md 20892-4442, USA. dorlic@nhgri.nih.gov

Circulation Research
|December 14, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Entropy for Prediction of MACEs in Myocarditis: A Cardiac MRI-based Biomarker of Myocardial Tissue Heterogeneity.

Radiology·2026
Same author

Coronary sinus reducer implantation for refractory angina: a national audit of UK practice.

Heart (British Cardiac Society)·2026
Same author

Impact of formalin fixation on biventricular parameters in cardiac diffusion tensor imaging: A pilot study in a miniature swine model.

The international journal of cardiovascular imaging·2026
Same author

Cardiac Magnetic Resonance Before Ventricular Tachycardia Ablation and During Follow-Up.

Circulation·2026
Same author

Lesion stratification with intracoronary imaging.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·2026
Same author

Myocardial Blood Flow Assessment and Reporting for Ischemic Heart Disease: Cardiac PET, MR, CT, and Echocardiography.

JACC. Cardiovascular imaging·2025

Adult stem cells show plasticity, regenerating organs like the heart. Further research is needed to understand and control stem cell behavior for regenerative medicine applications.

Area of Science:

  • Biomedical Science
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Adult stem cells are investigated for regenerative medicine.
  • Stem cell plasticity and transdifferentiation have been proposed as mechanisms for tissue renewal.
  • Controversy exists regarding transdifferentiation versus cell-cell fusion as the underlying mechanism.

Purpose of the Study:

  • To explore the role of stem cells in myocardial regeneration.
  • To understand the mechanisms of stem cell plasticity in the context of cardiac repair.
  • To identify methods for monitoring stem cell-based myocardial repair in animal models.

Main Methods:

  • Review of existing studies on stem cell plasticity and myocardial regeneration.
  • Discussion of proposed mechanisms, including transdifferentiation and cell-cell fusion.

Related Experiment Videos

  • Emphasis on the need for advanced technologies to track stem cells in vivo.

    • Main Results:

    • Evidence suggests stem cell plasticity contributes to myocardial regeneration, generating new cardiomyocytes in adults.
    • Stem cells appear to infiltrate both normal and infarcted myocardium.
    • Discrepancies exist in the reported extent of myocardial renewal across studies.

    Conclusions:

    • Stem cell plasticity is a significant factor in myocardial regeneration, challenging the postmitotic view of the adult heart.
    • Further research requires advanced instrumentation to track labeled stem cells and monitor repair over time in large animal models.
    • Identifying environmental cues and genetic/cellular mechanisms is crucial for regulating stem cell behavior in regenerative medicine.