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Related Experiment Videos

Morphological changes in breast tissue with menstrual cycle.

Rathi Ramakrishnan1, Seema A Khan, Sunil Badve

  • 1Department of Surgery, Northwestern University Medical School, Chicago, Illinois, USA.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
|December 14, 2002
PubMed
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Breast tissue morphology changes cyclically with the menstrual cycle. Histological analysis of surgical specimens accurately determines menstrual phase, aiding future breast cancer research.

Area of Science:

  • Reproductive Biology
  • Pathology
  • Oncology

Background:

  • Cyclical changes in breast tissue morphology related to the menstrual cycle have been debated.
  • Previous studies relied on autopsy material, lacking clinical validation.

Purpose of the Study:

  • To validate clinical assessment of menstrual cycle phase using breast tissue morphology.
  • To establish a method for retrospective analysis of archival breast tissue samples.
  • To inform epidemiological studies on breast cancer risk.

Main Methods:

  • Examined surgical breast specimens from 73 premenopausal women (excluding hormonal therapy users).
  • Assessed histological parameters: acinar cell layers, myoepithelial cell vacuolation, stromal edema, infiltrate, mitosis, and apoptosis.

Related Experiment Videos

  • Correlated morphological stage with menstrual dates and serum hormone levels (estrogen, progesterone).

    • Main Results:

    • Morphological staging concorded with menstrual dates in 74% of patients (P =.001).
    • Morphology and progesterone levels agreed in 80% of cases (P =.01).
    • High morphological scores significantly predicted luteal phase (odds ratio, 7.1).

    Conclusions:

    • Breast lobule morphology in surgical specimens reliably indicates menstrual cycle phase.
    • This method enables retrospective studies on menstrual cycle effects in breast tissue.
    • Clinical validation of menstrual phase determination via breast tissue morphology is established.