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Micellar electrokinetic chromatography: current developments and future.

Manuel Molina1, Manuel Silva

  • 1Department of Analytical Chemistry, Edificio Marie Curie (Anexo), Campus de Rabanales, University of Córdoba, Córdoba, Spain.

Electrophoresis
|December 14, 2002
PubMed
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This review covers advances in micellar electrokinetic chromatography (MEKC), focusing on improved sensitivity and selectivity using novel techniques and detection methods. Future directions like in-capillary reactions and microchip applications are also explored.

Area of Science:

  • Analytical Chemistry
  • Separation Science

Background:

  • Micellar electrokinetic chromatography (MEKC) is a powerful separation technique.
  • Advances are needed to enhance its sensitivity and selectivity for complex analyses.

Purpose of the Study:

  • To review recent methodological and instrumental progress in MEKC.
  • To highlight techniques for improving sensitivity and selectivity.
  • To discuss alternative detection methods and future research avenues.

Main Methods:

  • On-line preconcentration techniques (stacking and sweeping).
  • Use of nonconventional pseudostationary phases (nonionic/zwitterionic surfactants, mixed micelles, polymers).
  • Alternative detection methods: laser-induced fluorescence (LIF) and mass spectrometry (MS).

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Main Results:

  • MEKC sensitivity and selectivity are significantly enhanced by preconcentration and novel phases.
  • LIF and MS offer advantages over UV-absorption detection for MEKC analysis.
  • Various instrumental and methodological improvements are detailed.

Conclusions:

  • Recent advances have substantially improved MEKC performance.
  • Alternative detection methods provide valuable alternatives for MEKC applications.
  • Future research directions promise further advancements in MEKC technology.