Consequences of knocking out BMP signaling in the mouse

¹Cecil H. & Ida Green Center for Reproductive Biology Sciences, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. guang.zhao@utsouthwestern.edu

Genesis (New York, N.Y. : 2000)

|December 14, 2002

Abstract:

During the past two decades, a significant amount of data has been accumulated revealing the intriguing functions of bone morphogenetic proteins (BMPs) in all aspects of embryonic development and organogenesis. Numerous genes encoding BMPs, BMP receptors, and their downstream signal transducers have been mutated in the mouse through targeted mutagenesis. This review focuses on what is known about the role of BMP signaling in gastrulation, mesoderm formation, left-right asymmetry, neural patterning, skeletal and limb development, organogenesis, and gametogenesis as revealed by BMP-signaling mutants.

Related Experiment Videos

Consequences of knocking out BMP signaling in the mouse

Related Concept Videos

Hematologic malignancies associated with germ cell tumors.

WNT/beta-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells.

ERM is required for transcriptional control of the spermatogonial stem cell niche.

Developmental expression and function of Bmp4 in spermatogenesis and in maintaining epididymal integrity.

BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways.

Induction of primordial germ cells from pluripotent epiblast.

Identification of a Novel nkx2.3 Transgenic Reporter Specifically Visualizing Craniofacial Muscle Development in Zebrafish.

An Efficient Method for Neuron-Like Differentiation of SH-SY5Y Neuroblastoma Cells Using Retinoic Acid and Laminin-Rich Extracellular Matrix.

Expression of Growth Factor Genes in the Body Wall of the Holothurian Eupentacta fraudatrix During Regenerative Processes.

Generation and Characterization of a Rdh1-iCre Line to Study Uterine Glandular Biology.

Divergent Spatiotemporal Expression Patterns of Histone Deacetylases During Mouse Embryonic Tongue, Palate, and Mandible Development.

Ectopic Bulged Structures in Nkx2-1-KO and FoxE-KO Juveniles of Ciona robusta: Insights Into the Parallel Gene Regulatory System Before the Evolution of Thyroid Follicular Cells.

Dual-gene regulation of NGF overexpression and P75NTR knockdown enhances BMSC osteogenesis by suppressing pyroptosis.

Automated Standardization of the Shear-wave Elastography Effective Region Using DeepLabV3 Improves Malignancy Assessment in Thyroid Nodules: A Single-institution Multicampus Study.

Benzene Metabolite-Targeted Gene ATF7IP2 Drives Glutamate Metabolic Reprogramming to Promote Acute Myeloid Leukemia Initiation.

Loss of bves leads to cardiac contractile dysfunction and myocardial mitochondrial damage in zebrafish.

Oxytocin suppresses Endothelial-to-Mesenchymal transition to Mitigate cardiac fibrosis via the eNOS/cGMP/PKG pathway.

Ultrasound-triggered dual-mode therapy for heart failure via synchronized electrical stimulation and nitric oxide release.

Related Experiment Videos

Consequences of knocking out BMP signaling in the mouse

Abstract:

Related Concept Videos

Related Articles