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Synthesis and CNS activities of 2-methyl/5-chloro-8-(3-substituted propoxy)quinolines
J Thomas Leonard1, R Sivakumar, N Anbalagan
1Department of Pharmaceutical Chemistry, Vel's College of Pharmacy, Chennai, India.
Bollettino Chimico Farmaceutico
|December 17, 2002
Abstract:
In the present study, a series of 2-methyl/5-choloro-8-(3-substituted propoxy) quinolines were synthesized. The compounds were characterized by IR, 1H-NMR and elemental analysis. The compounds were investigated for anticonvulsant and decrease in the elevated motor activity by introceptive chemical stimuli (amphetamine antagonistic activity) at the dose level of 80 and 160 mg/kg. Compounds 2, 10, 11, 12 and 13 exhibited significant anticonvulsant and amphetamine antagonistic activity. Compounds 2 and 11 exhibited highest anticonvulsant and amphetamine activity respectively.