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Hypercalcitoninemia in infancy.

D B Cannarozzi, D D Canale, R K Donabedian

    Clinica Chimica Acta; International Journal of Clinical Chemistry
    |February 2, 1976
    PubMed
    Summary
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    Infants with neonatal hypocalcemia showed elevated immunoreactive calcitonin (iCT) levels. A combination of infant age and iCT levels correlated with hypocalcemia, suggesting stress may increase iCT sensitivity.

    Area of Science:

    • Neonatal Medicine
    • Endocrinology
    • Pediatric Biochemistry

    Background:

    • Neonatal hypocalcemia is a common condition in newborns.
    • Calcitonin is a hormone involved in calcium regulation.
    • Elevated calcitonin levels have been observed in certain neonatal conditions.

    Purpose of the Study:

    • To investigate the role of immunoreactive calcitonin (iCT) in neonatal hypocalcemia.
    • To explore the relationship between iCT levels, infant age, and serum calcium in neonates.
    • To assess the impact of neonatal diseases and stresses on iCT levels and calcium homeostasis.

    Main Methods:

    • Measurement of immunoreactive calcitonin (iCT) in 19 infants with neonatal hypocalcemia.
    • Analysis of the correlation between iCT levels, infant age, serum calcium, and neonatal conditions.

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  • Calculation of the ratio of iCT to infant age from conception.

    • Main Results:

    • Infants with neonatal hypocalcemia exhibited significantly elevated iCT levels (2-20 times adult values).
    • No strong correlation was found between infant age and iCT levels, or between iCT alone and serum calcium.
    • A significant correlation was observed between serum calcium and the ratio of iCT to infant age from conception.
    • Neonatal stresses appeared to be associated with increased iCT levels and heightened sensitivity to its hypocalcemic effects.

    Conclusions:

    • Both infant age and iCT levels, when considered together, may be linked to the development of neonatal hypocalcemia.
    • Neonatal stresses might play a role in modulating iCT levels and influencing calcium balance in infants.
    • Further research is warranted to elucidate the precise mechanisms of calcitonin action in neonatal hypocalcemia.