Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Methicillin resistant Staphylococcus].

Marcelo Marin1

  • 1Fundación del Centro de Estudios Infectológicos (FUNCEI), French 3037, 1425 Buenos Aires, Argentina.

Medicina
|December 17, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Antimicrobial susceptibility testing in clinically relevant non-fermenting gram-negative bacilli: recommendations from the Antimicrobial Agents Subcommittee of the Sociedad Argentina de Bacteriología, Micología y Parasitología Clínicas, Asociación Argentina de Microbiología].

Revista Argentina de microbiologia·2011
Same author

[Betalactam antibiotics combined with bectalactamases inhibitors. Amoxicillin-sulbactam].

Medicina·2008
Same author

Amoxicillin-sulbactam versus amoxicillin-clavulanic acid for the treatment of non-recurrent-acute otitis media in Argentinean children.

International journal of pediatric otorhinolaryngology·2005
Same author

[Guidelines for the management of bone and joint infections due to methicillin resistant staphylococci].

Medicina·2002
Same author

[Teicoplanin in the treatment of bone and joint infections due to methicillin resistant staphylococci. Experience in adult patients].

Medicina·2002
Same author

[Pharmacokinetic characteristics and antimicrobial spectrum of teicoplanin].

Medicina·2002
Same journal

Detection of VIM-3 in oral squamous cell carcinomas: methodological limitations.

Medicina·2026
Same journal

The importance of specific antibodies in VIM-3 research: addressing a key methodological flaw.

Medicina·2026
Same journal

[From the right to be cared for to the duty to care: Legal bases for the implementation of palliative care in Argentina].

Medicina·2026
Same journal

[Surrogacy].

Medicina·2026
Same journal

[The misunderstandings in interpreting the "diagnostic superiority of Artificial Intelligence" and the explainable Artificial Intelligence].

Medicina·2026
Same journal

[Artificial intelligence in medicine: between algorithmic opacity and clinical responsibility].

Medicina·2026
See all related articles

Methicillin-resistant Staphylococcus aureus (MRSA) is a growing threat, with resistance mechanisms like PBP2a impacting treatment. The emergence of vancomycin-intermediate Staphylococcus aureus (VISA) further complicates patient care.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Context:

  • Staphylococcus aureus is a significant pathogen in both hospital and community settings.
  • Antibiotic resistance in S. aureus has evolved rapidly since the introduction of penicillin.
  • Methicillin-resistant S. aureus (MRSA) and coagulase-negative staphylococci are globally prevalent, reaching nearly 50% in some regions.

Purpose:

  • To review the mechanisms and implications of antibiotic resistance in Staphylococcus aureus.
  • To highlight the challenges posed by methicillin resistance and the emergence of vancomycin resistance.

Summary:

  • Methicillin resistance in Staphylococci is primarily mediated by the mecA gene, encoding penicillin-binding protein PBP2a, which confers resistance to beta-lactam antibiotics.

Related Experiment Videos

  • MRSA strains exhibit heterogeneous resistance patterns, complicating empiric treatment strategies and increasing reliance on vancomycin.
  • The emergence of vancomycin-intermediate S. aureus (VISA) signifies a critical escalation in antimicrobial resistance, with vancomycin resistance linked to increased cell wall synthesis.

    • Impact:

    • The high prevalence of MRSA necessitates alternative treatment strategies and impacts infection control measures.
    • Understanding resistance mechanisms is crucial for developing new therapeutic approaches against resistant staphylococcal infections.
    • The rise of VISA strains poses a significant threat to public health, requiring vigilant monitoring and research into novel treatments.