Related Experiment Video

Updated: Sep 28, 2026

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
09:52

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

[Multivisceral infarcts are complication of invasive aspergillosis]

E Vázquez Muñoz1, M Morado Arias, J A Sobrino Daza

  • 1Servicios de Hematología y Cardiología, Hospital Universitario La Paz, Madrid.

Anales De Medicina Interna (Madrid, Spain : 1984)
|December 17, 2002
PubMed

Insights

Invasive aspergillosis can cause fatal multi-visceral infarcts in severely immunocompromised patients. This study highlights intravascular hyphae as a cause of septic emboli, an underestimated complication.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Pathology

Background:

  • Aspergillosis, caused by Aspergillus fumigatus, presents clinically with fever and respiratory distress, often fatal in severely immunocompromised individuals.
  • Aortic aspergillosis is a severe form occurring post-cardiac surgery.
  • Invasive aspergillosis requires awareness of diverse clinical manifestations.

Observation:

  • Two cases of invasive aspergillosis complicated by multiple visceral infarcts are presented.
  • Infarcts involved the liver, spleen, kidneys, pancreas, thyroid, and brain.
  • Necropsy confirmed intravascular hyphae within infarcted areas, forming septic emboli.

Findings:

  • Intravascular hyphae of Aspergillus fumigatus can lead to septic emboli.
  • Multi-visceral infarcts are a significant, potentially underestimated complication of invasive aspergillosis.
  • The study emphasizes the need for vigilance regarding this fungal infection's presentations.

Implications:

  • Clinicians must recognize multi-visceral infarcts as a potential consequence of invasive aspergillosis.
  • Increased awareness is crucial given the rising population of immunocompromised patients.
  • Early diagnosis and management are vital for improving outcomes in invasive aspergillosis.

More Related Videos

Infection of Zebrafish Larvae with Aspergillus Spores for Analysis of Host-Pathogen Interactions09:42

Infection of Zebrafish Larvae with Aspergillus Spores for Analysis of Host-Pathogen Interactions

Published on: May 16, 2020

A Model of Acute Lung Injury Following Visceral Ischemia-Reperfusion by Supra-Coeliac Aortic Cross Clamping in Rats06:50

A Model of Acute Lung Injury Following Visceral Ischemia-Reperfusion by Supra-Coeliac Aortic Cross Clamping in Rats

Published on: August 15, 2025

Related Concept Videos

Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
Anastomoses01:19

Anastomoses

In human anatomy, anastomosis refers to a connection or opening between two things, particularly between blood vessels or other tubular structures. The term is derived from the Greek term 'anastomosis,' which means 'outlet' or 'opening.' This natural network of connections plays a critical role in the survival and functionality of the human body.
Anastomoses can be formed at arterial, venous, and lymphatic vessels.
Arterial Anastomosis: These occur between arteries. They are most common in...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...