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Plasma carnitine and body composition.

G Cederblad

    Clinica Chimica Acta; International Journal of Clinical Chemistry
    |March 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Plasma carnitine levels are higher in men than women and increase with age. Dietary changes did not significantly alter daily carnitine excretion in a healthy individual.

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    Area of Science:

    • Biochemistry
    • Human Physiology
    • Nutritional Science

    Background:

    • Carnitine is essential for energy metabolism, transporting fatty acids into mitochondria.
    • Understanding plasma carnitine levels and excretion is crucial for metabolic health assessment.

    Purpose of the Study:

    • To determine reference ranges for plasma carnitine in healthy adults.
    • To investigate the relationship between plasma carnitine and factors like age and body composition.
    • To compare daily urinary carnitine excretion under different dietary conditions.

    Main Methods:

    • Plasma carnitine levels were measured in 16 men and 45 women without muscular disorders.
    • Statistical analysis was used to assess relationships with age, body composition, and plasma lipids.

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  • Urinary carnitine excretion was compared during ordinary and controlled gruel diets.

    • Main Results:

    • Mean plasma carnitine was significantly higher in men (57.3 ± 12.8 µmol/l) than women (46.5 ± 12.4 µmol/l).
    • Plasma carnitine showed a significant positive correlation with age but not with body composition or lipid profiles.
    • Daily urinary carnitine excretion did not differ significantly between the ordinary and gruel diet periods.

    Conclusions:

    • Established reference values for plasma carnitine in healthy adults, highlighting sex-based differences.
    • Age is a significant factor influencing plasma carnitine, independent of body composition.
    • Dietary intake, within the tested range, does not appear to significantly affect 24-hour urinary carnitine excretion.