Related Experiment Video

Updated: Aug 18, 2026

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques
11:28

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques

Published on: March 13, 2015

Diabetes mellitus is equally frequent in chronic HCV and HBV infection

H Qureshi1, T Ahsan, S A Mujeeb

  • 1PMRC Research Centre, Department of Medicine, Jinnah Postgraduate Medical Centre, Diabetes Clinic, Mideast Medical Centre, Karachi.

JPMA. the Journal of the Pakistan Medical Association
|December 17, 2002
PubMed

Insights

Type 2 diabetes mellitus is equally common in Hepatitis B and C virus related liver disease. However, diabetes is significantly more prevalent in patients with chronic liver disease compared to healthy individuals.

Area of Science:

  • Hepatology
  • Endocrinology
  • Viral Hepatitis Research

Background:

  • Chronic liver disease associated with Hepatitis B virus (HBV) and Hepatitis C virus (HCV) affects millions globally.
  • The co-occurrence of type 2 diabetes mellitus (Type 2 DM) with chronic liver disease warrants investigation due to potential shared risk factors and pathophysiological mechanisms.

Purpose of the Study:

  • To investigate the association between type 2 diabetes mellitus and chronic liver disease caused by HBV or HCV infections.
  • To compare the prevalence of Type 2 DM in patients with HBV-related liver disease versus HCV-related liver disease.
  • To assess the prevalence of Type 2 DM in patients with chronic liver disease compared to healthy and diabetic controls.

Main Methods:

  • A cross-sectional study involving patients from a gastroenterology outpatient department, diabetic controls from a private clinic, and healthy controls from a blood bank.
  • Hepatitis B virus (HBV) and Hepatitis C virus (HCV) infections were diagnosed using ELISA.
  • Blood glucose levels were measured using a glucometer, with random sugar ≥ 200 mg/dl indicating diabetes.

Main Results:

  • Among 400 patients with chronic liver disease, 302 had HCV and 98 had HBV. Diabetes prevalence was 24.5% in HCV and 19.4% in HBV cases (not statistically significant).
  • In 410 healthy controls, diabetes was found in only 1 (5.6%) HCV-positive individual and none of the HBV-positive controls.
  • Diabetes was significantly more frequent in patients with liver cirrhosis than in those with chronic hepatitis (P < 0.01).

Conclusions:

  • Type 2 diabetes mellitus occurs with similar frequency in both HBV and HCV related liver diseases.
  • Diabetes is significantly more prevalent in individuals with chronic liver disease compared to the general population.
  • Pancreatic damage secondary to viral replication is a potential cause, and genetic factors may also play a role.
Abstract

More Related Videos

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection11:14

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection10:25

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

Published on: February 19, 2019

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Diabetes Mellitus: Introduction01:26

Diabetes Mellitus: Introduction

Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and long-term...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...