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Related Experiment Videos

Calcitonin: the other thyroid hormone.

Angela M Inzerillo1, Mone Zaidi, Christopher L H Huang

  • 1Mount Sinai Bone Program, Department of Medicine, Mount Sinai School of Medicine, and Bronx Veteran's Affairs Geriatric Research Education and Clinical Center (GRECC), New York, New York 10029, USA.

Thyroid : Official Journal of the American Thyroid Association
|December 17, 2002
PubMed
Summary

Calcitonin, a hormone from thyroid C cells, inhibits bone resorption and pain. It is used clinically for bone diseases and high calcium levels.

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Area of Science:

  • Endocrinology
  • Bone Biology
  • Pharmacology

Background:

  • Calcitonin is a hormone synthesized by thyroid parafollicular C cells.
  • It was initially identified for its ability to lower calcium levels in the blood (hypocalcemic factor).
  • Early research indicated calcitonin's role in inhibiting bone resorption.

Purpose of the Study:

  • To review the cellular and molecular mechanisms underlying calcitonin's physiological effects.
  • To explore the basis of calcitonin's clinical applications.
  • To provide an overview of calcitonin's actions on bone metabolism and pain.

Main Methods:

  • Review of existing literature on calcitonin.
  • Analysis of cellular and molecular studies on calcitonin's mechanism of action.

Related Experiment Videos

  • Examination of clinical data regarding calcitonin's therapeutic uses.

    • Main Results:

    • Calcitonin's primary site of action is the osteoclast, where it potently inhibits bone resorption.
    • Calcitonin exhibits significant analgesic properties.
    • Histologic and culture studies confirmed osteoclasts as the main target cells.

    Conclusions:

    • Calcitonin's potent antiresorptive and analgesic effects support its clinical utility.
    • It is a valuable therapeutic agent for Paget's bone disease, osteoporosis, and hypercalcemia of malignancy.
    • Understanding the cellular and molecular basis is key to its therapeutic application.