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Related Experiment Videos

I. Arginine.

H Tapiero1, G Mathé, P Couvreur

  • 1Faculté de pharmacie, université de Paris, CNRS UMR 8612, 5, rue Jean-Baptiste-Clément, 94200 Chatenay-Malabry, France. haimtapiero@aol.com

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|December 17, 2002
PubMed
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L-Arginine (Arg) is a vital amino acid influencing cardiovascular health, immune function, and cellular processes. Supplementation shows promise in improving conditions like hypertension and endothelial dysfunction.

Area of Science:

  • Biochemistry
  • Physiology
  • Nutrition Science

Background:

  • L-Arginine (Arg) is an essential or conditionally essential amino acid crucial for various physiological functions.
  • It serves as a precursor for urea, creatine, agmatine, and proteins, impacting energy metabolism and immune responses.
  • Normal plasma Arg concentrations vary based on nutritional status and developmental stage.

Purpose of the Study:

  • To review the functional importance of L-Arginine (Arg) in human health and disease.
  • To define the effective activity of Arg in various pathologies.
  • To highlight Arg's role as a precursor for nitric oxide (NO) synthesis.

Main Methods:

  • Literature review of studies investigating L-Arginine's physiological roles and therapeutic applications.

Related Experiment Videos

  • Analysis of Arg's involvement in metabolic pathways, including the urea cycle and nitric oxide synthesis.
  • Examination of clinical data on Arg administration in cardiovascular and metabolic conditions.

    • Main Results:

    • Systemic or oral Arg administration improved cardiovascular function and reduced myocardial ischemia in coronary artery disease patients.
    • Arg reduced blood pressure and renal vascular resistance in hypertensive individuals.
    • Arg administration reversed endothelial dysfunction in hypercholesterolemic patients and smokers, despite unchanged plasma Arg levels.

    Conclusions:

    • L-Arginine (Arg) is a critical precursor for nitric oxide (NO) synthesis, essential for vascular relaxation and cardiovascular health.
    • NO derived from Arg plays roles in neurotransmission, immune response, and signaling.
    • Dysregulation of NO pathways, influenced by Arg availability and oxidative stress, contributes to pathologies like atherosclerosis and endothelial dysfunction.