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[Allogeneic bone marrow transplantation for the treatment of Bruton disease]
Xiaojun Huang1, Hongxia Shi, Nailan Guo
1Institute of Hematology, People's Hospital, Peking University, Beijing 100044, China.
Objective:
To explore the efficacy of allogeneic bone marrow transplantation (allo-BMT) for the treatment of Bruton disease.
Methods:
HLA-matched sibling bone marrow transplantation was performed for the treatment of 2 cases of X-linked agammaglobulinemia. One of them received allo-BMT twice.
Results:
Recovery of hematopoiesis was gained at day 20 and day 13 after allo-BMT in the two cases respectively. Serum immunoglobin rose gradually to normal level in three months. Their humoral immuno-system was reconstituted and life quality improved. These two patients are still in disease-free survival for 13 and 2 years respectively. There was no serious graft-versus-host-disease.
Conclusion:
Stem cell transplantation is a choice for the treatment of Bruton disease.