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Affinity labeling of the nuclear vitamin D receptor with nonsteroidal alkylating agents
Ana Fernández-Gacio1, Carlos Fernández-Marcos, Narasimha Swamy
1Bioorganic Chemistry and Structural Biology, Section in Endocrinology, Diabetes and Metabolism, Department of Medicine, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA.
Bioorganic & Medicinal Chemistry Letters
|December 17, 2002
Abstract:
Synthesis of an affinity alkylating non steroidal mimic of 1alpha,25-dihydroxyvitamin D(3) and its radiolabeled counterpart is presented. We also report the affinity labeling of the VDR-ligand binding domain (VDR-LBD) with this analogue.