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The preparation of (S)-aspartate semi-aldehyde appropriate for use in biochemical studies
Sarah J Roberts1, Jonathan C Morris, Renwick C J Dobson
1Department of Plant and Microbial Sciences, University of Canterbury, Christchurch, New Zealand.
Bioorganic & Medicinal Chemistry Letters
|December 17, 2002
Abstract:
We report two three-step syntheses of (S)-aspartate semi-aldehyde, an important synthetic and biosynthetic precursor, from diprotected aspartic acid. The first synthesis proceeds via a thioester, the second via a Weinreb amide. Each route yields pure (S)-aspartate semi-aldehyde in excellent yield. (S)-Aspartate semi-aldehyde prepared in this manner has proved appropriate as a substrate for detailed enzyme studies.