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The use of substrate engineering in biohydroxylation
Anna de Raadt1, Herfried Griengl
1Institute of Organic Chemistry, Technical University Graz, Stremayrgasse 16, A-8010, Graz, Austria.
Current Opinion in Biotechnology
|December 17, 2002
Abstract:
In the biohydroxylation of nonactivated carbon atoms, substrate engineering has been found to be a very useful and simple means to influence substrate acceptance and the regioselectivity and stereoselectivity of this transformation. Recently, this methodology has been applied to the hydroxylation of a large number of compounds including cycloalkane carboxylic acids, ketones, amines, amides and alcohols.