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Antibody discovery: phage display
Titus Kretzschmar1, Thomas von Rüden
1MorphoSys AG, Lena-Christ-Strasse 48, D-82152, Martinsried, Germany. tik@morphosys.com
Current Opinion in Biotechnology
|December 17, 2002
Summary
Phage display is a powerful method for discovering human antibodies quickly. This technology has successfully identified a therapeutic antibody currently in regulatory review for market approval.
Area of Science:
- Biotechnology
- Immunology
- Molecular Biology
Background:
- Phage display is a versatile in vitro selection technique.
- It enables the isolation of specific proteins, such as antibodies, from large combinatorial libraries.
Purpose of the Study:
- To highlight the utility of phage display for antibody discovery.
- To showcase its application in identifying therapeutic antibodies.
Main Methods:
- Utilizing diverse antibody libraries for phage display selection.
- High-throughput screening and characterization of selected antibody candidates.
Main Results:
- Phage display facilitates the rapid selection of high-quality human antibodies.
- The technology has led to the identification of a fully human therapeutic antibody.
Conclusions:
- Phage display is a robust and efficient technology for antibody discovery.
- It has significant potential for developing novel therapeutic antibodies, as evidenced by a candidate antibody progressing through regulatory approval.