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Sample Preparation for Endopeptidomic Analysis in Human Cerebrospinal Fluid
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Identification of neuropeptide FF-related peptides in human cerebrospinal fluid by mass spectrometry

Odile Burlet-Schiltz1, Honoré Mazarguil, Jean-Christophe Sol

  • 1Institut de Pharmacologie et de Biologie Structurale, CNRS UMR 5089, 205 route de Narbonne, 31077, Toulouse, France.

FEBS Letters
|December 17, 2002
PubMed

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Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...