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Plasma hepatocyte growth factor levels after open heart surgery for congenital heart disease
1Department of Thoracic and Cardiovascular Surgery, Wakayama Medical College, Kimiidera, Wakayama, Japan. komaih@mail.wakayama-med.ac.jp
Background:
Hepatocyte growth factor (HGF) is a polypeptide which acts protectively against endothelial cell dysfunction. A high plasma level of HGF is shown when the endothelium is injured. We measured plasma HGF levels during and after open heart operations for congenital heart disease, to elucidate its involvement with endothelial cell injury.
Experimental Design:
prospective study.
Setting:
perioperative setting.
Patients:
18 children electively operated upon for congenital heart disease using CPB.
Results:
Plasma HGF levels (ng/ml) before cardiopulmonary bypass (CPB) were 0.36+/-0.07 in 10 children (S-group) who were older and with simpler diseases, and 0.48+/-0.12 in 8 children (C-group) who were younger and with relatively complex diseases. HGF levels significantly increased after CPB, and gradually decreased thereafter. Plasma HGF levels 3 and 6 hours after CPB were significantly greater in the C-group than in the S-group (1.13+/-0.12 vs 1.68+/-0.1 6 3 hours after, and 1.09+/-0.19 vs 2.35+/-0,43 6 hours after; p<0.05 for both). There were significant positive correlations between HGF levels 6 hours after CPB and the duration of the CPB, the aortic crossclamping time, and plasma thrombomodulin levels just after CPB in all patients (p<0.05 for all).
Conclusions:
This data suggests that increased HGF levels are associated with endothelial cell injury induced by CPB, and that the increases are much greater in younger patients with complex anomalies.
