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[Multidisciplinary therapy for peritoneal dissemination using peritonectomy].
Yutaka Yonemura1, Kazuo Kinoshita, Shigeru Takahashi
1Dept. of Gastric Cancer, Dept. of Peritoneal Dissemination, Shizuoka Cancer Center.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|December 18, 2002
Summary
Aggressive treatment for peritoneal dissemination, including peritonectomy and perioperative chemotherapy, shows promise. Complete tumor resection is crucial for improving patient prognosis in these advanced cancer cases.
Area of Science:
- Oncology
- Surgical Oncology
- Gastrointestinal Oncology
Context:
- Peritoneal dissemination presents a significant challenge in advanced cancers, including gastric, colon, and ovarian.
- Traditional treatments often have limited efficacy for widespread peritoneal disease.
Purpose:
- To evaluate the efficacy of a multimodal approach combining peritonectomy with perioperative chemotherapy for peritoneal dissemination.
- To identify prognostic factors influencing survival in patients with peritoneal carcinomatosis.
Summary:
- Fifty-seven patients with peritoneal dissemination from gastric, colon, ovarian cancers, and mesothelioma underwent peritonectomy with intraoperative chemo-hyperthermia.
- Five-year survival rates were 18% for gastric cancer and 38% for colon cancer.
- Complete tumor resection (cytoreduction) was the most significant positive prognostic factor.
Impact:
- This multimodal therapy, particularly with complete cytoreduction, offers a powerful strategy for managing peritoneal dissemination.
- Improved survival rates suggest the potential of aggressive surgical and chemotherapeutic interventions.