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Syntheses of novel substituted-boranophosphate nucleosides
Kamesh Vyakaranam1, Geeta Rana, Bernard F Spielvogel
1Department of Chemistry and Biochemistry, Michael Faraday Laboratories, Northern Illinois University, DeKalb, IL 60115, USA.
Nucleosides, Nucleotides & Nucleic Acids
|December 18, 2002
Abstract:
A number of substituted (borano) nucleic acids, 3'-[diethylphosphite(cyano, carboxy, or carbamoyl) borano] deoxynucleosides (3a-4c) and 5'-[diethylphosphite(cyano or carboxy) borano] deoxynucleosides (6a-7d) were prepared by a variety of synthetic procedures. The syntheses of the pyrophosphates (2a-2c), as precursors for 3a-4c, are also described.