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Published on: August 20, 2014
Grafting sulfobetaine monomer onto the segmented poly(ether-urethane) surface to improve hemocompatibility
1Center of Research on Surface and Interface Chemical Engineering and Technology, Nanjing University, Nanjing, 210093, People's Republic of China.
Journal of Biomaterials Science. Polymer Edition
|December 18, 2002
Summary
Researchers developed a new non-thrombogenic biomaterial by modifying polyurethane surfaces. Grafting a sulfobetaine structure onto ozone-activated poly(ether-urethane) films prevented platelet adhesion, showing potential for biomedical applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Surface Modification
Background:
- Polyurethanes are common blood-contacting biomaterials but require improved hemocompatibility for advanced applications.
- Surface modification is a key strategy to enhance biomaterial hemocompatibility.
- Non-thrombogenic materials are crucial for reducing blood clot formation in medical devices.
Purpose of the Study:
- To synthesize a novel non-thrombogenic biomaterial by modifying polyurethane surfaces.
- To improve the hemocompatibility of segmented poly(ether-urethane) (SPEU) films.
- To evaluate the potential of a sulfobetaine-grafted SPEU surface for biomedical applications.
Main Methods:
- Ozonization of SPEU films to introduce peroxide groups.
- Graft polymerization of N,N'-dimethyl (methacryloyloxyethyl) ammonium propanesulfonate (DMAPS) onto ozone-activated SPEU.
- Characterization using ATR-FTIR, XPS, and contact angle measurements.
- Hemocompatibility assessment via platelet-rich plasma (PRP) adhesion studies and scanning electron microscopy.
Main Results:
- Graft polymerization of DMAPS onto SPEU surface was confirmed by ATR-FTIR and XPS.
- The SPEU-g-PDMAPS surface exhibited increased hydrophilicity.
- No platelet adhesion was observed on the grafted films after incubation with PRP for 60 and 180 minutes.
- SPEU film showed significant platelet adhesion, serving as a control.
Conclusions:
- The novel SPEU-g-PDMAPS biomaterial demonstrates excellent non-thrombogenic properties.
- Surface modification with sulfobetaine structures effectively enhances hemocompatibility.
- This sulfobetaine-grafted biomaterial shows significant potential for various biomedical applications requiring blood contact.
