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Related Experiment Videos

Increased CCR4 expression in cutaneous T cell lymphoma.

Katalin Ferenczi1, Robert C Fuhlbrigge, JackL Pinkus

  • 1Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

The Journal of Investigative Dermatology
|December 18, 2002
PubMed
Summary

Chemokine receptor CCR4 and its ligands TARC/CCL17 and MDC/CCL22 are elevated in cutaneous T cell lymphoma (CTCL). This explains the accumulation of skin-homing T cells in CTCL lesions.

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Area of Science:

  • Immunology
  • Dermatology
  • Oncology

Background:

  • Chemokines mediate leukocyte trafficking to specific tissues.
  • CCR4 is a chemokine receptor linked to T cell skin homing.
  • Cutaneous T cell lymphoma (CTCL) is a malignancy of skin-homing T cells.

Purpose of the Study:

  • To investigate CCR4 and its ligands (TARC/CCL17, MDC/CCL22) expression in CTCL.
  • To analyze the coexpression of skin-homing molecules CLA and CCR4 in CTCL patients.
  • To understand the mechanism of T cell accumulation in CTCL skin lesions.

Main Methods:

  • Analysis of CCR4 and CLA expression in peripheral blood and skin biopsies.
  • Quantification of TARC/CCL17 and MDC/CCL22 in CTCL lesions.
  • Comparison of T cell phenotypes between CTCL patients and healthy individuals.

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Main Results:

  • Significantly increased percentages of CLA+CCR4+ T cells in the blood of CTCL patients compared to healthy controls.
  • High levels of CLA+CCR4+ T cells found in CTCL skin lesions.
  • Abundant expression of TARC/CCL17 and MDC/CCL22 observed in CTCL lesions.

Conclusions:

  • Elevated CCR4 expression on skin-homing T cells contributes to their accumulation in CTCL.
  • CCR4 ligands TARC/CCL17 and MDC/CCL22 are upregulated in CTCL skin lesions.
  • These findings provide insights into the pathogenesis of CTCL and T cell homing to the skin.