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Published on: January 5, 2017
[The systemic manifestations of ulcerative colitis]
Hong Lu1, Jiaming Qian, Lihua Wang
1Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Extra-intestinal manifestations are common in ulcerative colitis (UC), particularly in extensive and severe cases. Their occurrence is linked to UC activity and lesion severity, not prognosis.
Area of Science:
- Gastroenterology
- Immunology
- Clinical Medicine
Context:
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
- Extra-intestinal manifestations (EIMs) are common in UC patients.
- Understanding the relationship between UC location/extent and EIMs is crucial for patient management.
Purpose:
- To investigate the association between the location and extent of ulcerative colitis (UC) and its extra-intestinal manifestations (EIMs).
- To analyze the incidence and patterns of EIMs in relation to UC severity and activity.
Summary:
- A retrospective review of 392 UC cases revealed a high incidence of EIMs (20.9%).
- Extensive colitis showed a higher incidence of EIMs compared to proctitis.
- EIMs were significantly more frequent in severe UC cases and associated with active disease, except for specific conditions like ankylosing spondylitis and primary sclerosing cholangitis.
Impact:
- EIMs in UC are closely related to the extent and severity of intestinal lesions and disease activity.
- Joints, hepatobiliary system, skin, mouth, and eyes are the most frequently affected organs.
- While EIMs correlate with UC characteristics, they do not appear to be related to patient prognosis.
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