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Signaling pathways mediate the neuroprotective effects of GDNF
1Division of Neuropathology, Institute of Pathology, Munich Technical University, Munich, Germany. neff@neuropathologie-muenchen.de
Annals of the New York Academy of Sciences
|December 18, 2002
Abstract:
We show that the glial cell line-derived neurotrophic factor (GDNF) activates the PI3K/Akt-signaling pathway in human neuroblastoma cells that express functional Ret-receptor complexes. Consistent with this finding we show PI3K-dependent Bad-inactivation by binding to 14-3-3 proteins in response to GDNF. Using differential display techniques we detected several cDNA clones differentially expressed after treatment with GDNF or 6-OHDA.