Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A case of frontal network amnesia.

K Tanji1, K Suzuki, T Fujii

  • 1Department of Neurology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan. kaztanji@neurol.med.tohoku.ac.jp

Journal of Neurology, Neurosurgery, and Psychiatry
|December 18, 2002
PubMed
Summary

Bilateral subcortical infarcts caused amnesia by disrupting thalamofrontal circuits, leading to recall difficulties. This distinct amnesic pathology differs from conventional memory system disruptions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Persistent left unilateral apraxia and a disconnection theory.

Behavioural neurology·2014
Same author

Hyperlalia: a right cerebral hemisphere syndrome.

Behavioural neurology·2014
Same author

Is disturbed transfer of learning in callosal agenesis due to a disconnection syndrome?

Behavioural neurology·2014
Same author

Crossed non-dominant hemisphere syndrome in a right-hander.

Behavioural neurology·2014
Same author

A patient with difficulty of object recognition: semantic amnesia for manipulable objects.

Behavioural neurology·2014
Same author

A selective impairment in the phonological output lexicon.

Behavioural neurology·2014

Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Subcortical infarcts can lead to complex neurological deficits, including memory impairment.
  • Understanding the specific neural circuits involved in amnesia is crucial for diagnosis and treatment.

Observation:

  • A 63-year-old man presented with amnesic syndrome and frontal lobe signs following bilateral subcortical infarcts.
  • The patient exhibited severe voluntary recall deficits but relatively preserved recognition.
  • Neuroimaging revealed lesions in the left thalamus and right globus pallidus/internal capsule.

Findings:

  • Bilateral thalamofrontal circuit disruption was identified as the likely cause of amnesia.
  • Lesions affected the dorsomedial thalamus and anterior limb of the internal capsule, impacting thalamofrontal connectivity.

Related Experiment Videos

  • The mammillothalamic tracts and anterior thalamic nuclei remained intact, differentiating this case from other amnesic syndromes.

    • Implications:

    • This case highlights a distinct pattern of amnesia resulting from thalamofrontal circuit damage.
    • It suggests the need to differentiate this thalamofrontal amnesia from amnesias associated with the Papez circuit or Delay-Brion system.
    • Further research into thalamofrontal circuit function in memory is warranted.