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[Contraception and neurology].

Caroline Combes1, Aimée Redondo, Alain Rey

  • 1Service de Neurochirurgie, Hôpital Beaujon, 100, boulevard Général-Leclerc, 92118 Clichy Cedex, France. caroline.combes@bjn.ap-hop-paris.fr

Annales De Medecine Interne
|December 18, 2002
PubMed
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Oral contraceptives interact with neurological diseases. Women with vascular risk factors or cerebral venous thrombosis history should avoid them. Discuss migraine and epilepsy drug interactions individually.

Area of Science:

  • Neurology
  • Endocrinology
  • Pharmacology

Background:

  • Oral contraceptives are widely used by genitally active women.
  • Interactions between oral contraceptives and neurological diseases require careful consideration.
  • Vascular disorders are a primary concern due to oral contraception's risk factor status.

Purpose of the Study:

  • To clarify the interactions between oral contraception (low- and high-dose) and major neurological diseases in women.
  • To provide guidance on the safe use of oral contraceptives in women with neurological conditions.

Main Methods:

  • Review of existing literature on oral contraceptive use and neurological diseases.
  • Analysis of risk factors and contraindications for oral contraception in specific neurological conditions.

Related Experiment Videos

  • Discussion of drug interactions between oral contraceptives and treatments for neurological disorders.

    • Main Results:

    • Oral contraception is a risk factor for vascular disorders, especially with co-existing risk factors like hypertension, smoking, or diabetes.
    • Low-dose oral contraceptives may be suitable for women without vascular risk factors.
    • A history of cerebral venous thrombosis is a formal contraindication for all oral contraceptives.
    • Migraine with aura requires individualized assessment due to vascular risk.
    • Oral contraceptives do not affect epilepsy but can be affected by anti-seizure drugs; non-inducing drugs are preferred.
    • Oral contraception may worsen certain hormone-receptor-positive brain tumors (meningiomas, hemangioblastomas); use is contraindicated unless hormone receptors are negative.
    • Multiple sclerosis is not influenced by oral contraception.

    Conclusions:

    • Careful patient selection and risk assessment are crucial when prescribing oral contraceptives to women with neurological diseases.
    • Contraindications and potential drug interactions must be thoroughly evaluated.
    • Individualized management is necessary, particularly for conditions like migraine and epilepsy.