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Updated: Sep 28, 2026

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis
Published on: December 18, 2019
[Multiple enchondromatosis: Ollier's disease]
W Schwarz1, J Hardes, M Schulte
1Abteilung für Unfallchirurgie,Hand- und Wiederherstellungschirurgie, Universität Ulm. winfried.schwarz@extern.uni-ulm.de
Abstract:
In contrast to solitary enchondroma,patients with multiple enchondromatosis of bone (Ollier's disease) get affected in childhood by bone swelling and growth retardation. In adults, the main problem is the risk of malign transformation up to 40%.Pain, increasing local tumor and thinning of the corticalis are the typical clinical and radiological signs of transformation to a low grade chondrosarcoma. There is no need for a regular radiological screening. If a malign transformation occurs,marginal or wide resection of the lesion should be performed.
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