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Exploring the interface between metallo-proteinase activity and growth factor and cytokine bioavailability
John L Fowlkes1, Margaret K Winkler
1Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, 800 Marshal Street, Slot 900, Little Rock, AR 72202, USA. fowlkesjohnl@uams.edu
Cytokine & Growth Factor Reviews
|December 19, 2002
Summary
Metzincins, including matrix metallo-proteinases (MMPs), regulate key cytokines and growth factors. Targeting these metallo-proteinases offers a novel approach to control extracellular peptide bioavailability.
Area of Science:
- Biochemistry
- Molecular Biology
- Cell Biology
Background:
- Metallo-proteinases are crucial for tissue remodeling, cell motility, and growth.
- The metzincin family, including MMPs, is increasingly linked to cytokine and growth factor regulation.
Purpose of the Study:
- To review the role of metzincins in modulating the extracellular environment.
- To highlight how metzincins influence the bioavailability of key cytokines and growth factors.
Main Methods:
- Literature review of studies on metzincins and their targets.
- Analysis of mechanisms by which metzincins affect cytokine and growth factor activity.
Main Results:
- Metzincins influence the extracellular availability of transforming growth factor-beta (TGF-beta), TNF-alpha, IGFs, and HB-epidermal growth factor (EGF).
- Specific metzincin mechanisms impact the activation and release of these signaling molecules.
Conclusions:
- Metzincins are key regulators of extracellular peptide bioavailability.
- Targeting metzincins presents a potential strategy for controlling cytokine and growth factor actions.