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Related Experiment Videos

Cow's milk proteins/allergens.

Jean-Michel Wal1

  • 1Laboratoire d'Immuno-Allergie Alimentaire, Service de Pharmacologie et d'Immunologie, INRA-CEA, CEA de Saclay, Gif sur Yvette, France. wal@cea.fr

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|December 19, 2002
PubMed
Summary

Cow's milk proteins (CMPs) can be allergens, with epitopes found throughout the molecule. Allergenicity is complex, making it hard to predict reactions or use peptides for desensitization.

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Area of Science:

  • Immunology
  • Food Science
  • Allergology

Background:

  • Cow's milk allergy (CMA) is a significant health concern.
  • Understanding cow's milk proteins (CMPs) and their allergenic properties is crucial.

Purpose of the Study:

  • To update data on the structure and function of allergenic CMPs.
  • To characterize the epitopes of CMPs.

Main Methods:

  • Literature synthesis of basic and recent publications.
  • Inclusion of clinical, epidemiological, biochemical, and immunochemical aspects.
  • Expert opinion for data selection.

Main Results:

  • Most CMPs are potential allergens, regardless of concentration.

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  • Allergenic epitopes are conformational and linear, distributed widely.
  • Conserved sequences in epitopes cause cross-reactivity with other mammalian milk proteins.

    • Conclusions:

    • No specific structure or function defines CMP allergenicity.
    • Human IgE response variability makes predicting allergenicity difficult.
    • Caution is advised when using peptides for desensitization or hydrolysates in diets.