Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rainforest endophytes and bioactive products.

Gary A Strobel1

  • 1Department of Plant Sciences, Montana State University, Bozeman, Montana 59717, USA. uplgs@montana.edu

Critical Reviews in Biotechnology
|December 19, 2002
PubMed
Summary

Endophytic microorganisms residing in plants offer a promising source of novel compounds to combat rising health issues from cancers and drug-resistant microbes. Bio-prospecting rainforests can yield valuable natural products for human, plant, and animal health solutions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Marvellous Muscodor spp.: Update on Their Biology and Applications.

Microbial ecology·2020
Same author

Microbial Flora Associated with the Halophyte-<i>Salsola imbricate</i> and Its Biotechnical Potential.

Frontiers in microbiology·2018
Same author

Functional Characterization of Endophytic Fungal Community Associated with <i>Oryza sativa</i> L. and <i>Zea mays</i> L.

Frontiers in microbiology·2017
Same author

An Insight into the Secondary Metabolism of Muscodor yucatanensis: Small-Molecule Epigenetic Modifiers Induce Expression of Secondary Metabolism-Related Genes and Production of New Metabolites in the Endophyte.

Microbial ecology·2016
Same author

An endophytic Coniochaeta velutina producing broad spectrum antimycotics.

Journal of microbiology (Seoul, Korea)·2015
Same author

Characterization of an Endophytic Gloeosporium sp. and Its Novel Bioactivity with "Synergistans".

Microbial ecology·2014

Area of Science:

  • Microbiology
  • Natural Products Chemistry
  • Pharmacognosy

Background:

  • Increasing global health challenges posed by cancers, drug-resistant bacteria, parasitic protozoans, and fungi necessitate novel therapeutic agents.
  • Endophytes, microorganisms residing within plant tissues, represent a largely untapped reservoir of diverse bioactive compounds.
  • The study of endophytes is crucial for discovering new chemical entities with potential applications in medicine and agriculture.

Purpose of the Study:

  • To explore the potential of endophytic microorganisms from rainforests as a source of novel bioactive compounds.
  • To outline methods for isolating and characterizing these endophytes and their metabolites.
  • To highlight the significance of endophytes in addressing human, plant, and animal health concerns.

Main Methods:

Related Experiment Videos

  • Isolation of endophytic microorganisms from plant tissues.
  • Culturing of endophytes and extraction of compounds from culture filtrates.
  • Bioassay-guided fractionation and spectroscopic methods for isolation and characterization of bioactive substances.
  • Review of previously identified compounds such as taxol, cryptocin, and ambuic acid.

Main Results:

  • Endophytes produce a wide array of unusual and valuable organic substances.
  • Several bioactive compounds, including taxol and pseudomycins, have been identified from endophytic microbes.
  • The potential for discovering novel therapeutic agents from unexplored plant-microbe interactions is substantial.

Conclusions:

  • Endophytes are a valuable resource for discovering novel bioactive compounds to address critical health challenges.
  • Bio-prospecting rainforests for endophytes offers a strategic approach to identifying new therapeutic leads.
  • Further research into endophytic microorganisms is essential for unlocking their full potential for human and ecological health.