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Updated: Sep 28, 2026

Supramaximal Intensity Hypoxic Exercise and Vascular Function Assessment in Mice
Published on: March 15, 2019
Hyperoxia improves maximal exercise with the self-contained breathing apparatus (SCBA)
Neil D Eves1, Stewart R Petersen, Richard L Jones
1Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada, T6G 2H9.
Abstract:
The effects of hyperoxia on maximal exercise while breathing from a self-contained breathing apparatus (SCBA) were studied in 25 males. Each participant completed three graded exercise tests (GXT) for the assessment of maximal oxygen uptake (VO(2max)): two with 20.95 +/- 0.28% O(2) and the third (GXT(40)) while breathing hyperoxia (40.64 +/- 1.29% O(2)). No significant differences were found between the two normoxic tests, except for a 16W increase in maximal power output (PO(max)) in the second trial (GXT(21)). Compared to GXT(21), hyperoxia significantly increased VO(2max) and PO(max) by 10.0 +/- 3.8% and 10.2 +/- 7.1%, respectively. This was likely due to an increase in O(2) delivery as suggested by the significantly higher oxyhemoglobin saturation. The increase in VO (2max) with hyperoxia was similar to the increase in carbon dioxide production (9.3 +/- 6.5%). No other significant di.fferences were found at maximal exercise. However, at the intensity that elicited VO(2max) in GXT(21), pulmonary ventilation and SCBA mask pressure were significantly lower during GXT(40), suggesting a decrease in the work of breathing. These findings could have significant implications for occupations that involve heavy work with SCBA.
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