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Related Experiment Videos

[Bladder controller in bladder function reconstruction of paraplegic dogs].

Shibo Wang1, Chunlin Hou, Aimin Chen

  • 1Department of Orthopaedic, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.

Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]
|December 19, 2002
PubMed
Summary

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A bladder controller combined with sacral deafferentation successfully restored bladder function in paraplegic dogs, enabling controlled voiding through electrical stimulation.

Area of Science:

  • Neuroscience
  • Urology
  • Biomedical Engineering

Context:

  • Spinal cord transection at T(10) leads to paraplegia and loss of bladder control.
  • Restoring bladder function is a significant challenge in managing spinal cord injuries.
  • Current treatments for neurogenic bladder dysfunction have limitations.

Purpose:

  • To evaluate the efficacy of a bladder controller in conjunction with sacral deafferentation for restoring bladder function in paraplegic dogs.
  • To assess the functional recovery of bladder voiding mechanisms post-intervention.

Summary:

  • Four paraplegic dogs with T(10) spinal cord transection underwent dorsal rhizotomy at S(1-3) and received implanted electrodes connected to receivers.
  • Daily electrical stimulation via the bladder controller facilitated micturition, with urine volumes ranging from 80-140 ml.

Related Experiment Videos

  • Vesicography confirmed bladder filling and bladder neck opening during stimulation, with residual urine volumes between 15-20 ml.

    • Impact:

    • Demonstrates a potential therapeutic strategy for restoring bladder function in spinal cord injury patients.
    • Highlights the combined effectiveness of neuromodulation and surgical intervention.
    • Provides a foundation for further research into advanced neuroprosthetic devices for bladder management.