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Methinks it is like a folding curve
Rajgopal Srinivasan1, George D Rose
1Jenkins Department of Biophysics, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA. raj@grserv.med.jhmi.edu
Biophysical Chemistry
|December 19, 2002
Abstract:
Most often, the unfolded state of peptides and proteins has been modeled as a statistical random coil. Here, we suggest an alternative model based on the presence of a significant, temperature-dependent conformational bias in the unfolded population. Conformational bias is suggested by our calculations [Proc. Natl. Acad. Sci. USA 96 (1999) 14258-14263], and it is found in recent studies of both proteins and peptides. The imposition of even a modest bias would transform our assessment of the folding problem.