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Loss of G protein gamma 7 alters behavior and reduces striatal alpha(olf) level and cAMP production
William F Schwindinger1, Kelly S Betz, Kathryn E Giger
1Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania 17822, USA.
Abstract:
The G protein beta gamma-dimer is required for receptor interaction and effector regulation. However, previous approaches have not identified the physiologic roles of individual subtypes in these processes. We used a gene knockout approach to demonstrate a unique role for the G protein gamma(7)-subunit in mice. Notably, deletion of Gng7 caused behavioral changes that were associated with reductions in the alpha(olf)-subunit content and adenylyl cyclase activity of the striatum. These data demonstrate that an individual gamma-subunit contributes to the specificity of a given signaling pathway and controls the formation or stability of a particular G protein heterotrimer.
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